“Viking Disease” Might Have Actually Come From This Ancient Human Cousin

When the Vikings raided the isles of Northern Europe, they left in their wake a crippling hand condition. Officially called Dupuytren’s contracture after the French surgeon who discovered it in 1831, it's often dubbed the “Viking disease” after the infamous Scandinavians who introduced it. But new genetic evidence suggests the real culprit is a far more distant cousin — our kissing cousins, the Neanderthals.
In a study published Wednesday in the journal Molecular Biology and Evolution, researchers at the Karolinska Institutet in Sweden combed through over 7,800 individual genomes collected from three biobanks in the US, UK, and Finland. They found 61 genes associated with Dupuytren’s contracture, three of which appeared Neanderthal in origin and may be involved in disease susceptibility.
“This is a case where the meeting with Neanderthals has affected who suffers from [the] illness,” Hugo Zeberg, study lead and assistant professor at the Karolinska Institutet, said in a press release.
Dupuytren’s contracture results in a build-up of scar tissue in the hand from inflammation, which causes the fingers to bend permanently. The condition is largely considered genetic — more common in people of Northern European descent — but other factors like alcohol and tobacco use, diabetes, age, and sex (men being three times more likely) also appear to contribute to one’s chance of developing the disease.
“Viking Disease” Might Have Actually Come From This Ancient Human Cousin